The improper management of conventional ammunition and explosives poses significant safety and security risks. Frequent ammunition depot explosions and diversions from ammunition stocks of state actors testify to the relevance of the issue to Africa. Overcoming challenges to effective national ammunition management can be a formidable task in itself. This paper considers the challenges to and scope for action on ammunition management in Africa. It is argued that concerted efforts by African states and their international partners will be essential to effectively limiting risks of undesirable explosive events and ammunition diversions on the continent.